Nutrition, Epigenetics and Complex Birth Defects

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منابع مشابه

Prenatal Nutrition and Birth Defects

Evidence of human birth defects dating back over three thousand years is reported in archeological literature. Excavated ruins of ancient Babylon revealed detailed reports of infant defects.1 Achondroplastic dwarfs (failure to develop healthy cartilage at the ends of the long bones, resulting in a form of congenital dwarfism) have been unearthed in ancient Egyptian tombs. Pictures drawn on anci...

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Epigenetics and Nutrition

Epigenetics refers to the study of heritable changes in gene expression that do not depend on the DNA sequence itself. Those changes alter the phenotype without any change in the genotype and can be influenced by several factors. The environment, the way of living, habits, age, parental nutritional state during gestation and others are amongst the major factors influencing chromatin remodeling....

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Nutrition and Epigenetics

Cardiovascular diseases (CVDs), diabetes, obesity and cancer are polygenic in nature and their prevalences and mortality vary depending upon genetic susceptibility and the presence of phenotype risk factors. The heritability of variant phenotypes may depend on the intake of proinflammatory or anti-inflammatory nutrients, for their expression as phenotypes or their suppression. Genes are importa...

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Nutrition, Epigenetics, and Diseases

Increasing epidemiological evidence suggests that maternal nutrition and environmental exposure early in development play an important role in susceptibility to disease in later life. In addition, these disease outcomes seem to pass through subsequent generations. Epigenetic modifications provide a potential link between the nutrition status during critical periods in development and changes in...

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Role of nutrition in pregnancy with phenylketonuria and birth defects.

OBJECTIVE The maternal phenylketonuria (PKU) syndrome is caused by high blood phenylalanine (Phe) levels during pregnancy, leading to a host of birth defects, especially microcephaly and congenital heart disease (CHD). For finding whether the maternal PKU syndrome could be prevented, an international collaborative study was organized to evaluate treatment with a Phe-restricted diet. Blood Phe l...

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ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2010

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.24.1_supplement.401.3